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KMID : 0360319920240010064
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Journal of Korean Cancer Research Association
1992 Volume.24 No. 1 p.64 ~ p.72
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Changes in the Distribution and Function of Lymphocytes in Peripheal Blood of Cancer Patients Undergoing Radiotherapy
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Abstract
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The role of immunological factors in the development and course of human malignancy has been extensively studied, and evidence now indicates that an impaired immunity may affect the clinical response and prognosis of cancer patients. If the
host's
immune status is important in its defense against cancer, it is imperative that the varying effects of treatment modalities on the immune system be evaluated.
This study was designed to determine the extent and duration of changes in the serum IgG level, proportion and proliferative responses of T and B cells, and differentiation responses of B cells of peripheral blood obtained from each cancer
patient
undergoing therapeutic irradiation. Radiation affected neither significant changes in the mean values nor IgG-secreting response of B lymphocytes. During irradiation, the mean numbers of lymphocytes were decreased, varying from 44.3 percent to
48.2
percent of pretreatment baseline. But this decrement was restored after completion of treatment. A decrease in proliferative response of mitogenstimulated lymphocytes was also noted during radiation. This radiation-induced depression of T cell
proliferation was almost recovered to the pretreament values by 6-week post-irradiation, but that of B lymphocytes persisted until about 12 weeks after completion of therapy.
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